The most important element of management is surgical drainage and removal of necrotic tissue with dental extraction where indicated.
Antimicrobial
Localized without systemic symptoms:
Antibiotic use is not recommended
Infection with facial swelling but without severe or systemic symptoms:
Amoxicillin 500mg (child 25mg/kg) PO TID
PLUS
Metronidazole 500mg (child 10mg/kg) PO BID
Alternative:
Amoxicillin/Clavulanic acid 500/125mg (child 25/6.25 mg/kg) PO TID
OR
Clindamycin 300mg (child7.5mg/kg) PO TID
Infection with severe features or systemic involvement (including Ludwig angina):
Arrange urgent transfer to hospital.
Benzylpenicillin 3 million IU (1.8g) (if in ICU 4 million IU (2.4g)) (child 80 000 IU (50mg)/kg) IV Q4H
PLUS
Metronidazole 500mg (child 12.5mg/kg) IV BID
Alternative:
If benzylpenicillin is not available replace with:
Ampicillin 2g (child 50mg/kg) IV Q4H
OR
Cefazolin 2g (child 50mg/kg) IV TID
OR
Clindamycin 600mg (child 15mg/kg) IV TID (no need for metronidazole if clindamycin is used)
Comments and Duration of Therapy
For infection requiring hospital admission, take blood cultures and send operative specimens for culture.
Severe features include:
- Significant facial swelling and pain
- Neck swelling
- Trismus
- Dysphagia
- Difficulty breathing
Systemic features include:
- Fever >38 degrees C
- Tachycardia
- Pallor
- Diaphoresis
Duration:
Infection with facial swelling but without severe or systemic symptoms: Treat for 5 days
Infection with severe features or systemic involvement (including Ludwig angina): Change to oral antibiotics once improving. Treat until signs and symptoms of infection have resolved (10-14 days).
Infection following dentoalveolar surgery:
Most infections can be managed by dental treatment alone.
If there are systemic features of infection or the patient is immunocompromised treat as ‘Infection with facial swelling but without severe or systemic symptoms’, or ‘Infection with severe features or systemic involvement’, depending on severity.
See Necrotising Soft Tissue Infection in Skin and Soft Tissue Infections.