Haemolytic Anaemia

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Haemolytic anaemia results from an increase in the rate of red cell destruction in the intravascular or  in the reticuloendothelial system in some pathological disorders 

Clinical presentation: 

• Pallor, jaundice, splenomegaly
• Anaemia, Reticulocytosis, indirect hyperbilirubinemia, and haemoglobinuria Pharmacological Treatment 

Immunosuppressants 

A: prednisolone (PO) 1–1.5mg/kg/day for 1-3 weeks until Hb > 10g/dl 

AND/OR 

S: cyclosphophamide (IV) 50mg/kg/day for 4days 

If no response; 

A: folic acid (PO) 5mg 24hourly should be given for 1to 3months. 

OR 

B: blood transfusion if anaemia is severe 

OR  

S*: High dose human immunoglobulin G (IV) 400mg/kg/day for 5days 

Surgical Management 

• Splenectomy may be considered in those who fail to respond to pharmacological treatment