Pre Labour Rupture of Membranes (PROM) - Antibiotic prophylaxis

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This is rupture of amniotic membranes at term before onset of labour

For full management of PROM see main Zimbabwe STG

If >24 hours or pyrexia in labour. Early delivery should be effected:

 

Medicine

Adult Dose

Frequency

Duration

 

benzylpenicillin iv

2MU

6 hourly

until delivery

and

chloramphenicol iv

500mg

6 hourly

 

and

metronidazole iv

500mg

8 hourly

until delivery

Switch to oral antibiotics for 7 days after delivery:

 

Medicine

Adult Dose

Frequency

Duration

 

amoxicillin po

500mg

3 times a day

7 days

and

metronidazole po

400mg

3 times a day

7 days