Rhesus Incompatibility

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Incompatibility between an infant’s blood type and that of its mother, resulting in destruction of the  infant’s red blood cells (hemolytic anemia) during pregnancy and after birth by antibodies from its  mother’s blood circulation. 

Investigations 

  • Maternal Blood group+ Rhesus factor
  • Paternal blood group+ Rhesus factor
  • Infant Cord blood at delivery for grouping, FBC, Coombs test to detect maternal antibodies and Total Billirubin

Prevention of Rhesus isoimmunisation 

If the mother is Rhesus negative give 

C: anti D immunoglobin 300microgram within 72hours of delivery 

Antepartum 

C: anti D immunoglobulin (IM)at 28-32weeks of gestation 

Abortion in Rhesus negative mother give 

C: anti D immunoglobulin 100microgram (IM) within 72hours of abortion 

Note: For the management of other medical conditions in pregnancy e.g. Malaria, Peripartum cardiomyopathy, Diabetes and Renal disease in pregnancy refer to specific chapters in this guideline.