Bleeding Esophageal Varices
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Esophageal varices are collateral veins within the wall of the esophagus that project directly into the lumen. Acute variceal bleeding is a fatal complication in patients with liver cirrhosis. In patients with decompensated liver cirrhosis accompanied by ascites or hepatic encephalopathy, acute variceal bleeding is associated with a high mortality rate.
Pharmacological Treatment
S: octreotide (SC) 50–100µg 8hourly for 3days (infusion 50µg/hour for 72hours up to 5days)
OR
S: terlipressin: Adult (body weight up to 50 kg): Initially 2 mg every 4 hours until bleeding controlled, then reduced to 1 mg every 4 hours if required, maximum duration 48 hours. Adult (body weight 50 kg and above): Initially 2 mg every 4 hours until bleeding controlled, reduced if not tolerated to 1 mg every 4 hours, maximum duration 48 hours
AND
Band ligation of beeding esophageal varices (EVL); 3 – 6 shoots per session.
OR
Sclerotherapy (Histo Acryl Glue Inj. 5 %;( mixed with Lipiodol at a ratio 1:1) Ethanolamine oleate 5%); given 2 -5ml per varix up to 20ml per session.
AND
B: ceftriaxone (IV) 1g 24hourly for 7days
Note: Blood transfusion (PRBC, PLT concentrates and FFP) when required.