Aspergilosis

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Clinical presentation  

  • Cough
  • Fever
  • Chest pain
  • Difficulty breathing
  • Hemoptysis  ranging  from  mild  to severe
  • Wheezing may be noted on auscultation
  • Mucous plugs upon coughing
  • Tachypneic and is rapidly progressive worsening
  • Hypoxemia

Investigations 

  • Chest X-ray and CT, pulmonary aspergillosis classically manifests as a halo sign and later an air crescent sign
  • Sputum Culture
  • Bronchoscopy (BAL)

Non-pharmacological Treatment 

  • Surgical treatment
  • Bronchial artery embolization (for life threatening hemoptysis)

Pharmacological Treatment 

D: itraconazole (PO) 100-200mg 24hourly 6-12weeks