Appendix- 2: Antibiotics not recommended (WHO List- 2021)
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Objectives
The use of the fixed-dose combinations of multiple broad-spectrum antibiotics listed here is not evidence-based, nor recommended in high-quality international guidelines. WHO does not recommend their use in clinical practice.
Antibiotic Combination
- acetylspiramycin/metronidazole
- amikacin/cefepime
- amoxicillin/bacillus coagulans/cloxacillin
- amoxicillin/bacillus coagulans/dicloxacillin
- amoxicillin/clavulanic acid/lactic ferments
- amoxicillin/clavulanic acid/lactobacillus acidophilus
- amoxicillin/clavulanic acid/nimesulide
- amoxicillin/cloxacillin
- amoxicillin/cloxacillin/lactic acid
- amoxicillin/cloxacillin/lactobacillus acidophilus/serrapeptase
- amoxicillin/cloxacillin/lactobacillus lactis
- amoxicillin/cloxacillin/serrapeptase
- amoxicillin/dicloxacillin
- amoxicillin/dicloxacillin/saccharomyces boulardii
- amoxicillin/flucloxacillin
- amoxicillin/flucloxacillin/lactobacillus acidophilus
- amoxicillin/metronidazole
- amoxicillin/pivsulbactam
- amoxicillin/sulbactam
- ampicillin/bacillus coagulans/cloxacillin
- ampicillin/cloxacillin
- ampicillin/cloxacillin/lactobacillus acidophilus
- ampicillin/cloxacillin/saccharomyces boulardii
- ampicillin/dicloxacillin
- ampicillin/dicloxacillin/lactobacillus acidophilus
- ampicillin/flucloxacillin
- ampicillin/lidocaine/sulbactam
- ampicillin/oxacillin
- ampicillin/sultamicillin
- ascorbic acid/metamizole sodium/penicillin g /streptomycin
- azithromycin/cefixime
- azithromycin/cefixime/lactobacillus acidophilus
- azithromycin/cefpodoxime proxetil
- azithromycin/fluconazole/secnidazole
- azithromycin/levofloxacin
- azithromycin/ofloxacin
- benzyl penicillin/streptomycin
- bromelains/doxycycline/lactobacillus reuteri/lactobacillus rhamnosus/ornidazole
- bromhexine/sulfamethoxazole/trimethoprim
- cefaclor/clavulanic acid
- cefadroxil/clavulanic acid
- cefadroxil/trimethoprim
- cefalexin/trimethoprim
- cefdinir/clavulanic acid
- cefepime/sulbactam
- cefepime/tazobactam
- cefixime/cefpodoxime proxetil
- cefixime/clavulanic acid
- cefixime/clavulanic acid/lactobacillus acidophilus
- cefixime/cloxacillin
- cefixime/cloxacillin/lactobacillus acidophilus
- cefixime/dicloxacillin
- cefixime/lactobacillus acidophilus/ofloxacin
- cefixime/levofloxacin
- cefixime/linezolid
- cefixime/moxifloxacin
- cefixime/ofloxacin
- cefixime/ornidazole
- cefoperazone/sulbactam
- cefoperazone/tazobactam
- cefotaxime/sulbactam
- cefpodoxime proxetil/clavulanic acid
- cefpodoxime proxetil/cloxacillin/lactobacillus acidophilus
- cefpodoxime proxetil/dicloxacillin
- cefpodoxime proxetil/dicloxacillin/lactobacillus acidophilus
- cefpodoxime proxetil/levofloxacin
- cefpodoxime proxetil/ofloxacin
- cefpodoxime proxetil/sulbactam
- ceftazidime/sulbactam
- ceftazidime/tazobactam
- ceftazidime/tobramicin
- ceftibuten/clavulanic acid
- ceftriaxone/sulbactam
- ceftriaxone/tazobactam
- ceftriaxone/vancomycin
- cefuroxime axetil/clavulanic acid
- cefuroxime axetil/linezolid
- cefuroxime axetil/sulbactam
- cefuroxime/clavulanic acid
- cefuroxime/sulbactam
- chloramphenicol/tetracycline
- ciprofloxacin/metronidazole
- ciprofloxacin/ornidazole
- ciprofloxacin/tinidazole
- doxycycline/tinidazole
- erythromycin/sulfamethoxazole/trimethoprim
- erythromycin/trimethoprim
- fosfomycin/trimethoprim
- gatifloxacin/ornidazole
- kanamycin/penicillin g
- levofloxacin/metronidazole
- levofloxacin/ornidazole
- meropenem/sodium/sulbactam
- meropenem/sulbactam
- metronidazole/norfloxacin
- metronidazole/spiramycin
- metronidazole/tetracycline
- mezlocillin/sulbactam
- ofloxacin/ornidazole
- oleandomycin/tetracycline
- piperacillin/sulbactam
- rifampicin/trimethoprim
- sulfadiazine/sulfamethoxazole/trimethoprim