Dosing Guidelines For DR-TB

Group

Medicine

Weight-based daily dose

Formulation

Weight bands for patients older than 14 years

Usual upper daily dose

Comments

30-35

36-45

46-55

56-70

>70

A

Levofloxacin

250mg tab

3

3

4

4

4

1.5g

500mg tab

1.5

1.5

2

2

2

750mg tab

1

1

1.5

1.5

1.5

Moxifloxacin

Standard dose

400mg tab

1

1

1

1

1

400mg

High dose

400mg tab

1 or 1.5

1 or 1.5

1.5 or 2

2

2

800mg

As used in the standardized shorter MDR-TB regimen

Bedaquiline

100mg tab

4 tabs od for first 2 weeks; then 2 tabs on 3 times a week for 22 weeks

400mg

Linezolid

600mg tab

<15y

<15y

1

1

1

1.2g

B

Clofazimine

50mg cap or tab

2

2

2

2

2

100mg

100mg cap or tab

1

1

1

1

1

100mg

Cycloserine

10-15 mg/kg

250mg cap

2

2

3

3

3

1g

C

Ethambutol

15-25 mg/kg

400mg tab

2

2

3

3

3

-

Delamanid

50mg tab

2bd

2bd

2bd

2bd

2bd

200mg

Pyrazinamide

20-30 mg/kg

400mg tab

3

4

4

4

5

-

500mg tab

2

3

3

3

4

Medicine

Recommended Dosing

Levofloxacin 100mg scored, 

dispersible tablets

15-20mg/kg/day

Cycloserine 125mg capsules

15-20mg/kg/day

Clofazimine 50mg tablet

2-5mg/kg/day

Linezolid 150mg, scored, dispersible tablets

10-12mg/kg once daily for children < 12 years who weigh 16kg or more; 15mg/kg once daily in children < 12 years who weigh less than 16kg; 10mg/kg once daily in children 12 years and above

*Bedaquiline 20mg tablet (Children ages six and above)

For children who weigh more than 30kg, the standard adult dose of 400mg daily for 14 days followed by 200mg three times a week for an additional 22 weeks is given. For children who weigh 16-30kg, the recommended dosing is 200mg daily for 14 days followed by 100mg three times a week for an additional 22 weeks.

**Delamanid 25mg dispersible tablet (Children ages three years and above)

For children who weigh more than 35kg, the standard adult dose of 100mg twice daily is given (for a total daily dose of 200mg). For children who weigh 24-34kg, the recommended dosing is 50mg twice daily (for a total daily dose of 100mg). A practical dosing table for children based on weight is below.