Fresh Frozen Plasma

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FRESH FROZEN PLASMA

  • Contains all clotting factors
  • Comes in volumes of 200-300 ml
  • Fresh frozen plasma (FFP) should be thawed before use using water bath at 30- 37 degrees {If water bath is not available, a plastic basin with lukewarm water or cold tap water can be used}. Never use hot water

Do not use whole blood, fresh frozen plasma, or red cell suspension to expand blood volume

  • Once thawed, FFP must be used immediately. FFP must never be refrozen.
  • The patient needs further investigations; please refer to the central hospital.

 

Indications For Fresh Frozen Plasma

  • Replacement of single factor deficiencies (if single factor concentrates are not available)
  • Immediate reversal of warfarin effect
  • Vitamin K deficiency associated with active bleeding
  • Acute disseminated intravascular coagulopathy (DIC)
  • Thrombotic thrombocytopenic purpura (TTP)
    • May be used in massive transfusion or liver disease

Dose:

  • 15-20ml/kg

Side effects: 

  • Acute allergic reactions are common.
  • Febrile, non haemolytic reaction
  • Viral transmission
  • Bacterial contamination – sepsis

No justification for use in hypovolemia, nutritional support in protein losing states or/and plasma exchange except in TTP.  FFP transfusion does not require group and cross matching.