Use of Medicine in Renal Dysfunction/Impairment

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Note: Take great care when prescribing any medicine and carefully check medicine prescribing information (e.g. in BNF, MNF) regarding use in renal failure/impairment.Usually safe medicine:

• Doxycycline
• Erythromycin
• Penicillin
• Phenytoin
• Rifampicin

Use with care  in reduced doses:

• Amoxycillin
• Chloramphenicol (avoid in severe impairment)
• Cotrimoxazole
• Diazepam
• Digoxin
• Insulin
• Isoniazid-containing medicines
• Pethidine (increase dose interval, avoid in severe impairment)
• Phenobarbitone
• Propranolol
• Antiretroviral medicines

Avoid using:

• ACE inhibitors (eg. Captopril)
• Aspirin and other NSAIDS (eg. Ibuprofen, Indomethacin, diclofenac)
• Codeine
• Ethambutol
• Gentamycin
• Nalidixic acid
• Nitrofurantoin
• Streptomycin