Neurosyphillis

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TREATMENT

PHARMACOLOGICAL

• Higher penicillin doses are necessary to ensure that levels in the CSF do not fall below required amount throughout the course of treatment

 Adults:

• Give Benzylpenicillin 2.4MU IV 6 hourly for 14 days then
• Give Benzathine Penicillin 2.4 MU IM once weekly for 3 consecutive weeks

Alternatively, if confirmed hypersensitivity to penicillin:

• Doxycycline 200mg every 12 hours for 30 days
• Note: In pregnancy: substitute Doxycycline with Erythromycin 500mg 6 hourly for 30 days