Head Injuries - antibiotic prophylaxis/treatment

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For more information on the management of head injuries see full Ghana STG. This section will only cover antibiotic use.

Pharmacological treatment - antibiotic prophylaxis/ treatment

For fracture base of skull 

Evidence Rating: [A]

  • Cloxacillin, IV, 

Adults

500 mg 6 hourly 

Children 

5-12 years; 250 mg 6 hourly 

1-5 years; 125 mg 6 hourly 

< 1 year; 62.5 mg 6 hourly 

For open skull fractures

  • Amoxicillin + Clavulanic Acid, IV, 

Adults 

600 mg 8 hourly

Children

25 mg/kg 6 hourly

And

  • Metronidazole, IV,

Adults

500 mg 8 hourly 

Children

7.5 mg/kg 8 hourly 

And

Evidence Rating: [B]

  • Benzylpenicillin, IV, 

Adults

1.2-2.4 g 6 hourly

Children

50 mg /kg 6 hourly