Sickle Cell Disease- prophylaxis and immunisation

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Pharmacological prophylaxis and immunisation

Severe Disease

• Amoxicillin + Clavulanic Acid, IV, 1.2 g and urgently transferred to a tertiary centre

Hydroxycarbamide, Aspirin, Opiates and/or Chronic transfusion therapy may be used under specialist care

Prevention of pneumococcal infections

• Pneumococcal conjugate vaccine 13 (PCV 13) vaccination in infancy, booster at 6 years

Referral Criteria

The presence of osteomyelitis, aseptic necrosis of the hip, acute chest syndrome and persistent jaundice after initial management as recommended above should warrant a referral to a specialist centre.