Evidence Rating: [A]
- Benzoyl peroxide 5% lotion, topical, apply daily (avoiding mouth, eyes and the mucous membranes)
And
- Clindamycin, 1% lotion or gel, topical, apply daily
Or
- Tretinoin 0.01% gel, topical, apply nocte (avoiding the sun, eyes, nostrils, mouth, mucous membrane and broken skin)
Caution: Retinoids (Tretinoin) are contraindicated in pregnancy
Or
- Adapalene 0.1% cream or gel, topical, apply thinly once daily (at night before sleep)