Impetigo

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Impetigo is a highly contagious superficial bacterial skin infection. It is common in neonates and children and may be associated with conditions such as scabies, eczema, lice infestation and herpes simplex infection as secondary infection. The condition does not cause any symptoms until four to 10 days after initial exposure. It usually improves within a week of treatment. 

There are two types of impetigo. The non-bullous type typically affects the skin around the nose and mouth, causing lesions to develop, that quickly burst to leave a yellow-brown crust. The other type, bullous  impetigo, typically affects the trunk causing fluid-filled blisters (bullae) to develop that burst after a few days to leave a yellow crust.

Both types of impetigo may leave behind marks when the crusts have cleared up, but these usually improve over the following days or weeks.

Its prevention involves good hygiene, regular hand-washing, trimming of fingernails to reduce breaking of the skin through scratching, and discouraging the sharing of towels and clothing.

Cause

  • Staphylococcus aureus 
  • Streptococcus pyogenes

Symptoms

  • Pus-filled blisters and sores on the body or scalp

Signs

  • Superficial, fragile fluid-filled blisters
  • Irregular spreading ulcers with yellow crusts

Investigations

  • Often no test required 
  • Microscopy and culture of the exudate from the blisters (except in recurrent or severe cases)

TreatmentTreatment Objectives

  • To eradicate infection
  • To prevent transmission
  • To  reduce the risk of developing complications (e.g.cellulitis, septicaemia)
  • To identify and treat any predisposing condition

Non-pharmacological treatment

  • Antiseptic baths for all cases

Pharmacological treatment 

See sections below

Referral Criteria

Refer for hospital care and treatment if spreading rapidly or cellulitis, osteomyelitis or septicaemia develops.

Mild cases (few pustules without fever or systemic manifestations)

Evidence Rating: [B]

  • Mupirocin ointment, topical,

Adults and children

Apply 12 hourly for 7 days

Moderate to severe or extensive cases in patients without penicillin allergy

1st Line Treatment

  • Cloxacillin, IV,

Adults

500 mg 6 hourly for 3 - 5 days 

Children

10-18 years; 250-500 mg 6 hourly for 3-5 days

2-10 years; 125-250 mg 6 hourly for 3-5 days

< 2 years; 62.5-125 mg 6 hourly for 3-5 days

Then

  • Flucloxacillin, oral,

Adults 

500 mg 6 hourly for 5-7 days 

Children

10-18 years; 250-500 mg 6 hourly for 5-7 days

2-10 years; 125-250 mg 6 hourly for 5-7 days 

< 2 years; 62.5-125 mg 6 hourly for 5-7 days

Or

  • Amoxicillin + Clavulanic Acid, oral,

Adults 

625 mg 12 hourly for 5 -7 days 

Children

11-18 years; 625 mg 12 hourly for 5-7 days

6-10 years; 457 mg 12 hourly for 5-7 days

1-5 years; 228 mg 12 hourly for 5-7 days

< 1 year; 114 mg 12 hourly for 5-7 days

2nd line treatment

Evidence Rating: [B]

  • Cefuroxime IV, 

Adults

750 mg 8 hourly for 3-5 days 

Children

1 month-18 years; 20 mg/kg 8 hourly for 3-5 days 

Then 

  • Cefuroxime, oral,

Adults

250 mg 12 hourly 

Children

12-18 years; 250 mg 12 hourly

2-12 years; 15 mg/kg 12 hourly, max. 250 mg 12 hourly

3 months-2 years; 10 mg/kg max. 125 mg 12 hourly

Moderate to severe or extensive cases in patients with penicillin allergy:

  • Azithromycin, oral

Adult

500 mg daily for 3-5 days

Children

10 mg/kg body weight daily for 3 days 

< 6 months; not recommended because of a risk of pyloric stenosis