Evidence Rating: [B]
- Mupirocin ointment, topical,
Adults and children
Apply 12 hourly for 7 days
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Impetigo is a highly contagious superficial bacterial skin infection. It is common in neonates and children and may be associated with conditions such as scabies, eczema, lice infestation and herpes simplex infection as secondary infection. The condition does not cause any symptoms until four to 10 days after initial exposure. It usually improves within a week of treatment.
There are two types of impetigo. The non-bullous type typically affects the skin around the nose and mouth, causing lesions to develop, that quickly burst to leave a yellow-brown crust. The other type, bullous impetigo, typically affects the trunk causing fluid-filled blisters (bullae) to develop that burst after a few days to leave a yellow crust.
Both types of impetigo may leave behind marks when the crusts have cleared up, but these usually improve over the following days or weeks.
Its prevention involves good hygiene, regular hand-washing, trimming of fingernails to reduce breaking of the skin through scratching, and discouraging the sharing of towels and clothing.
Cause
Symptoms
Signs
Investigations
TreatmentTreatment Objectives
Non-pharmacological treatment
Pharmacological treatment
See sections below
Referral Criteria
Refer for hospital care and treatment if spreading rapidly or cellulitis, osteomyelitis or septicaemia develops.
Evidence Rating: [B]
Adults and children
Apply 12 hourly for 7 days
1st Line Treatment
Adults
500 mg 6 hourly for 3 - 5 days
Children
10-18 years; 250-500 mg 6 hourly for 3-5 days
2-10 years; 125-250 mg 6 hourly for 3-5 days
< 2 years; 62.5-125 mg 6 hourly for 3-5 days
Then
Adults
500 mg 6 hourly for 5-7 days
Children
10-18 years; 250-500 mg 6 hourly for 5-7 days
2-10 years; 125-250 mg 6 hourly for 5-7 days
< 2 years; 62.5-125 mg 6 hourly for 5-7 days
Or
Adults
625 mg 12 hourly for 5 -7 days
Children
11-18 years; 625 mg 12 hourly for 5-7 days
6-10 years; 457 mg 12 hourly for 5-7 days
1-5 years; 228 mg 12 hourly for 5-7 days
< 1 year; 114 mg 12 hourly for 5-7 days
2nd line treatment
Evidence Rating: [B]
Adults
750 mg 8 hourly for 3-5 days
Children
1 month-18 years; 20 mg/kg 8 hourly for 3-5 days
Then
Adults
250 mg 12 hourly
Children
12-18 years; 250 mg 12 hourly
2-12 years; 15 mg/kg 12 hourly, max. 250 mg 12 hourly
3 months-2 years; 10 mg/kg max. 125 mg 12 hourly
Adult
500 mg daily for 3-5 days
Children
10 mg/kg body weight daily for 3 days
< 6 months; not recommended because of a risk of pyloric stenosis