6.1 Pregnancy

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Anti-TB treatment should be started as soon as the diagnosis is made, and the full course of treatment should be given. The basic principles of treatment of TB in pregnancy are the same. Most anti-TB drugs are safe to use during pregnancy.

• All pregnant women should also receive preventive treatment for isoniazid-related peripheral neuropathy. For this, they should be given oral Vit B6 (Pyridoxine) at a dosage of 10 mg/day along with their anti-TB drugs for the entire duration of treatment.
• Rifampicin can increase the metabolism of vitamin K, resulting in clotting disorders. Prophylactic administration of vitamin K to the mother and the neonate is recommended to prevent the risk of post-natal haemorrhage when the mother has received rifampicin during pregnancy:

For the Mother:
Vitamin K; PO: 10 mg/day for the 15 days prior to expected date of delivery

For the new-born infant: Prophylactic IM vitamin K to prevent haemorrhagic disease of the new-born.
Vitamin K; IM: 1 mg as a single dose, the day of birth

• In Previously Treated pregnant cases, fluoroquinolones like Lfx should be avoided and instead, 4FDC (RHEZ) for 6 months should be prescribed.